Mechanisms of vascular injury and remodeling

The Conte Lab conducts basic laboratory investigations that are focused on understanding and improving the healing response of blood vessels following angioplasty and bypass surgery, with the goal of improving the long-term results of these common operations. Specifically, the laboratory investigates the vascular biology of restenosis and the vessel wall response to injury. We are interested in the molecular pathways which govern the survival and growth of endothelial and smooth muscle cells at site of blood vessel injury. We have also had a long-standing interest in the local delivery of genes, small molecules and drugs to blood vessels. His research is funded by the National Institutes of Health and other extramural sources.

Recent Publications

Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS
The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells.
PloS one, [epublish] 911: e113480.
Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MS
D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jun-01-2013; 276: 2220-32.  Epub 2013 Mar 15.
Hiramoto JS, Owens CD, Kim JM, Boscardin J, Belkin M, Creager MA, Conte MS
Sex-based differences in the inflammatory profile of peripheral artery disease and the association with primary patency of lower extremity vein bypass grafts.
Journal of vascular surgery, Aug-01-2012; 562: 387-95; discussion 395.  Epub 2012 May 25.
Pillai PS, Leeson S, Porter TF, Owens CD, Kim JM, Conte MS, Serhan CN, Gelman S
Chemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients.
Inflammation, Feb-01-2012; 351: 98-113.
Nabzdyk CS, Lancero H, Nguyen KP, Salek S, Conte MS
RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology, Nov-01-2011; 3015: H1841-9.  Epub 2011 Aug 19.
Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS
Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization.
American journal of physiology. Heart and circulatory physiology, Jul-01-2011; 3011: H41-7.  Epub 2011 May 2.
Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MS
Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis.
The American journal of pathology, Oct-01-2010; 1774: 2116-23.  Epub 2010 Aug 13.
Conte MS
Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes.
Journal of vascular surgery, Sep-01-2010; 523 Suppl: 96S-103S.
Rybicki FJ, Mitsouras D, Owens CD, Whitmore A, Gerhard-Herman M, Wake N, Cai T, Zhou Q, Conte MS, Creager MA, Mulkern RV
Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts.
The international journal of cardiovascular imaging, Aug-01-2010; 266: 683-91.  Epub 2010 Mar 24.
Owens CD, Kim JM, Hevelone ND, Hamdan A, Raffetto JD, Creager MA, Conte MS
Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein.
Journal of vascular surgery, May-01-2010; 515: 1152-9.  Epub 2010 Mar 11.
Conte MS
Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) and the (hoped for) dawn of evidence-based treatment for advanced limb ischemia.
Journal of vascular surgery, May-01-2010; 515 Suppl: 69S-75S.
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